Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 10/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20425643 | 0.83 | OPRM1 (0.40) | CHRM1CHRM4CHRM5ALDH1A1MEN1 | |
| SCHEMBL2062840 | 0.83 | GRM5 (0.37) | CHRM1CHRM4CHRM5LMNAMEN1 | |
| SCHEMBL20425561 | 0.82 | TSHR (0.45) | CHRM1CHRM4CHRM5MEN1POLB | |
| SCHEMBL20425573 | 0.78 | GRM5 (0.36) | CHRM1CHRM4CHRM5LMNAMEN1 | |
| SCHEMBL2060564 | 0.78 | CHRM1 (0.43) | CHRM1CHRM4CHRM5ALDH1A1 | |
| SCHEMBL7479513 | 0.76 | ALDH1A1 (0.41) | LMNAALDH1A1POLBKMT2A | |
| SCHEMBL12533370 | 0.72 | ALDH1A1 (0.44) | CHRM1ALDH1A1MEN1KMT2AGRM5 | |
| SCHEMBL13080722 | 0.72 | HTR2C (0.47) | L3MBTL1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL11360559 | 0.72 | CHRM1 (0.36) | CHRM1CHRM4CHRM5ALDH1A1MEN1 | |
| SCHEMBL8221697 | 0.72 | GPR65 (0.48) | CHRM1CHRM4CHRM5GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | claimed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |