Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | TERT | O14746 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062840 | 0.85 | GRM5 (0.37) | CYP1A2MEN1KMT2AGRM5AKR1C3 | |
| SCHEMBL20425561 | 0.84 | TSHR (0.45) | MEN1KMT2AGRM5POLBCHRM1 | |
| SCHEMBL884784 | 0.83 | CHRM1 (0.42) | ALDH1A1MEN1KMT2AGRM5POLB | |
| SCHEMBL20425573 | 0.80 | GRM5 (0.36) | MEN1KMT2AGRM5POLBAKR1C3 | |
| SCHEMBL20440046 | 0.77 | ALDH1A1 (0.42) | OPRM1ALDH1A1KMT2AMAPK1OPRD1 | |
| SCHEMBL20425610 | 0.77 | ALDH1A1 (0.42) | OPRM1ALDH1A1KMT2AMAPK1OPRD1 | |
| SCHEMBL20425657 | 0.76 | SMN1; SMN2 (0.37) | OPRM1KMT2AMAPK1POLBOPRD1 | |
| SCHEMBL20439674 | 0.76 | SMN1; SMN2 (0.37) | OPRM1KMT2AMAPK1POLBOPRD1 | |
| SCHEMBL20425562 | 0.76 | SMN1; SMN2 (0.37) | OPRM1KMT2AMAPK1POLBOPRD1 | |
| SCHEMBL20425617 | 0.76 | FAAH (0.39) | OPRM1MEN1KMT2AOPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220048884-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. | 2022-02-17 | — | — | US | disclosed |
| WO-2018140876-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. (US) | 2018-08-02 | — | — | WO | disclosed |
| WO-2018140876-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. (US) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220048884-A1 | NRF2 ACTIVATOR | NFE2L2, KEAP1, NQO1 | OPRM1 1723/4885TDP2 3980/4885CYP1A2 287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.