Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.37 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | PDE6D | O43924 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851330 | 0.92 | LMNA (0.46) | LMNAGNAI3GNAO1GNAI1GBA1 | |
| SCHEMBL8851405 | 0.85 | ALDH1A1 (0.42) | GNAI3GNAO1GNAI1ITGB3ITGA2B | |
| SCHEMBL9282409 | 0.83 | LMNA (0.47) | LMNAGBA1PDE6D | |
| SCHEMBL8851562 | 0.81 | SIGMAR1 (0.42) | LMNAGNAI3GNAO1GNAI1SLC6A2 | |
| SCHEMBL8851192 | 0.81 | LMNA (0.44) | LMNAGNAI3GNAO1GNAI1GBA1 | |
| SCHEMBL30150922 | 0.80 | ALDH1A1 (0.43) | GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL28705710 | 0.79 | ITGB3 (0.43) | LMNAGNAI3GNAO1GNAI1ITGB3 | |
| Hydrochloric Acid SCHEMBL28703448 | 0.78 | ITGB3 (0.42) | LMNAGNAI3GNAO1GNAI1ITGB3 | |
| SCHEMBL8851878 | 0.77 | SLC6A4 (0.40) | LMNAGNAI3GNAO1GNAI1SLC6A2 | |
| SCHEMBL8851304 | 0.77 | ALDH1A1 (0.35) | GNAI3GNAO1GNAI1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |