SCHEMBL8854752

SCHEMBL8854752

COc1c(-c2ccccc2O)oc2ccccc2c1=O

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 9/20 0.72
CYP3A4 P08684 7/20 0.72
HSD17B10 Q99714 6/20 0.72
TSHR P16473 4/20 0.72
CYP2C9 P11712 3/20 0.72
CYP2C19 P33261 3/20 0.72
ABCG2 Q9UNQ0 3/20 0.67
ALDH1A1 P00352 6/20 0.60
HPGD P15428 5/20 0.60
MEN1 O00255 4/20 0.60
KMT2A Q03164 4/20 0.60
MAOA P21397 3/20 0.57
ABCB1 P08183 1/20 0.52
MAPT P10636 5/20 0.51
CYP2D6 P10635 2/20 0.51
TDP1 Q9NUW8 2/20 0.51
THRB P10828 1/20 0.51
ALOX15 P16050 1/20 0.51
HTT P42858 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL380906 0.84 KDM4E (1.00) KDM4ECYP3A4HSD17B10TSHRCYP2C9
SCHEMBL29727380 0.83 KDM4E (0.72) KDM4ECYP3A4HSD17B10TSHRCYP2C9
SCHEMBL1765291 0.82 KDM4E (0.84) KDM4ECYP3A4HSD17B10TSHRCYP2C9
SCHEMBL31675811 0.82 NMUR2 (0.71) KDM4ECYP3A4HSD17B10TSHRCYP2C9
SCHEMBL290080 0.82 NMUR2 (0.71) KDM4ECYP3A4HSD17B10TSHRCYP2C9
SCHEMBL5796864 0.81 ABCG2 (0.78) KDM4ECYP3A4HSD17B10TSHRCYP2C9
SCHEMBL3282447 0.81 KDM4E (0.71) KDM4ECYP3A4HSD17B10TSHRCYP2C9
SCHEMBL29993383 0.80 ABCG2 (1.00) KDM4ECYP3A4HSD17B10TSHRCYP2C9
SCHEMBL253523 0.80 ABCG2 (1.00) KDM4ECYP3A4HSD17B10TSHRCYP2C9
SCHEMBL28611642 0.80 KDM4E (0.54) KDM4ECYP3A4HSD17B10TSHRCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1837202-B Flavonols with blood-fat-lowering effect UNIV PLA 2ND MILITARY MEDICAL 2010-08-18 CN claimed
US-5626883-A VITAMIN C SUPPLEMENTS FOR IMMUNOLOGY METAGENICS, INC. 1997-05-06 US claimed
CN-1837202-B Flavonols with blood-fat-lowering effect UNIV PLA 2ND MILITARY MEDICAL 2010-08-18 CN disclosed
CN-1837202-A Flavonols with blood-fat-lowering effect UNIV PLA 2ND MILITARY MEDICAL (CN) 2006-09-27 CN disclosed
US-5626883-A VITAMIN C SUPPLEMENTS FOR IMMUNOLOGY METAGENICS, INC. 1997-05-06 US disclosed
WO-1995028084-A1 ASCORBIC ACID COMPOSITION PROVIDING ENHANCED HUMAN IMMUNE SYSTEM ACTIVITY METAGENICS, INC. (US) 1995-10-26 WO disclosed