Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.31 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855191 | 0.83 | KARS1 (0.53) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL9360372 | 0.74 | POLA1 (0.44) | KARS1LMNACYP3A4EP300 | |
| SCHEMBL8855376 | 0.72 | SRD5A2 (0.35) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL15732245 | 0.72 | EP300 (0.46) | ALOX15CYP3A4MAPTKDM4EFDPS | |
| SCHEMBL9359538 | 0.70 | KARS1 (0.34) | KARS1ALOX15CYP3A4MAPTFDPS | |
| SCHEMBL8855131 | 0.70 | KARS1 (0.51) | KARS1ALOX15LMNACYP3A4PDK1 | |
| SCHEMBL9359973 | 0.68 | CYP3A4 (0.50) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL8855258 | 0.64 | EP300 (0.32) | EP300 | |
| SCHEMBL12260908 | 0.64 | AR (0.54) | LMNACYP3A4FDPS | |
| SCHEMBL13201767 | 0.59 | FDPS (0.53) | HSD17B10CYP3A4MAPTCYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0472733-B1 | PHENANTHRENE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 1994-12-28 | — | — | EP | disclosed |
| US-5192817-A | Interleukin-1 inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0472733-A1 | PHENANTHRENE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-04 | — | — | EP | disclosed |