Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.47 |
| ▸ | FDPS | P14324 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855332 | 0.82 | CYP3A4 (0.54) | POLA1CYP3A4ALOX15MAPTUSP2 | |
| SCHEMBL9355660 | 0.71 | CYP3A4 (0.33) | CYP3A4MAPTUSP2HPGDCYP2C9 | |
| SCHEMBL29552651 | 0.71 | FDPS (0.37) | CYP3A4ALOX15MAPTUSP2HPGD | |
| SCHEMBL9360485 | 0.71 | LPAR1 (0.33) | CYP3A4MAPTUSP2HPGDCYP2C9 | |
| SCHEMBL9364236 | 0.70 | CYP3A4 (0.72) | POLA1CYP3A4ALOX15MAPTUSP2 | |
| SCHEMBL8855272 | 0.70 | MAPT (0.37) | CYP3A4MAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL8855173 | 0.70 | CYP3A4 (0.31) | CYP3A4MAPTALDH1A1 | |
| SCHEMBL8855310 | 0.70 | CYP3A4 (0.33) | CYP3A4MAPTALDH1A1PIK3CAPIK3CG | |
| 18-Hydroxyferruginol SCHEMBL32666150 | 0.68 | KARS1 (0.67) | POLA1CYP3A4ALOX15MAPTUSP2 | |
| 18-Hydroxyferruginol SCHEMBL18290210 | 0.68 | KARS1 (0.67) | POLA1CYP3A4ALOX15MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654343-A | NITRIC OXIDE SYNTHESIS INHIBITOR; TREATING ENDOTOXIC SHOCK | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| EP-0676196-A1 | NITROGEN MONOXIDE SYNTHESIS INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-11 | — | — | EP | disclosed |