Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.41 |
| ▸ | HTR3B | O95264 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | AGXT | P21549 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9355554 | 0.80 | MAOB (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6190936 | 0.79 | MAPT (0.44) | PNMTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27652264 | 0.75 | GRIN2B (0.49) | PNMTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL19437175 | 0.75 | HTR6 (0.41) | PNMTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7801553 | 0.73 | TAAR1 (0.61) | PNMTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4946932 | 0.73 | HSD11B1 (0.37) | TAAR1IDO1ALDH1A1 | |
| SCHEMBL6031658 | 0.73 | CHRM5 (0.53) | PNMTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27927705 | 0.72 | PNMT (0.48) | PNMTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7372584 | 0.70 | PNMT (0.52) | PNMTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL167780 | 0.70 | PNMT (0.56) | PNMTHTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629319-A | QUINDOLINE ALKALOIDS | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-05-13 | — | — | US | claimed |