Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 5/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315380 | 0.91 | PTAFR (0.43) | PTAFRGABRA5ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6317813 | 0.90 | PTAFR (0.43) | PTAFRGABRA5ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6315501 | 0.90 | NPC1 (0.44) | PTAFRGABRA5ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6315360 | 0.89 | GABRA5 (0.43) | PTAFRGABRA5ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6317599 | 0.86 | LMNA (0.59) | PTAFRALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL6315451 | 0.84 | ALDH1A1 (0.47) | GABRA5ALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL6323514 | 0.83 | ALDH1A1 (0.45) | GABRA5ALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL6315546 | 0.82 | ALDH1A1 (0.49) | GABRA5ALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL6316413 | 0.82 | ALDH1A1 (0.44) | GABRA5ALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL885658 | 0.81 | GABRA1 (0.47) | GABRA5LMNAGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937637-B1 | NEW N-ALKYL-HETEROCYCLYL CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2013-04-03 | — | — | EP | claimed |
| EP-1937637-A1 | NEW N-ALKYL-HETEROCYCLYL CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039615-A1 | NEW N-ALKYL-HETEROCYCLYL CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2007-04-12 | — | — | WO | claimed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | claimed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | claimed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | claimed |
| EP-1937637-A1 | NEW N-ALKYL-HETEROCYCLYL CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039615-A1 | NEW N-ALKYL-HETEROCYCLYL CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2007-04-12 | — | — | WO | disclosed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | PTAFR 1697/4885GABRA5 742/4885ALDH1A1 4444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.