Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7552930 | 0.87 | LTB4R (0.47) | MTNR1AMTNR1BPIN1CA1CA2 | |
| SCHEMBL7557806 | 0.87 | LTB4R (0.47) | MTNR1AMTNR1BPIN1CA1CA2 | |
| SCHEMBL7552940 | 0.87 | LTB4R (0.47) | MTNR1AMTNR1BPIN1CA1CA2 | |
| Hydrochloric Acid SCHEMBL8858324 | 0.86 | LTB4R (0.47) | MTNR1AMTNR1BPIN1CA1CA2 | |
| SCHEMBL13534458 | 0.82 | MTNR1A (0.42) | MTNR1AMTNR1BDRD2DRD3CHRM2 | |
| SCHEMBL7314503 | 0.82 | TDP1 (0.56) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL9040773 | 0.81 | MTNR1A (0.43) | MTNR1AMTNR1BPIN1CA1CA2 | |
| SCHEMBL9379902 | 0.77 | MTNR1A (0.45) | MTNR1AMTNR1BPIN1CA1CA2 | |
| SCHEMBL7111930 | 0.76 | DRD2 (0.46) | MTNR1AMTNR1BDRD2DRD3CHRM2 | |
| SCHEMBL9371775 | 0.75 | SMN1; SMN2 (0.49) | MTNR1AMTNR1BCA1CA2LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696137-A | TREATING DISEASES OF CENTRAL NERVOUS SYSTEM | BAYER AKTIENGESELLSCHAFT (DE) | 1997-12-09 | — | — | US | disclosed |
| US-5696136-A | TREATING DISEASES OF CENTRAL NERVOUS SYSTEM | BAYER AKTIENGESELLSCHAFT (DE) | 1997-12-09 | — | — | US | disclosed |
| US-5693653-A | ADMINISTERING AN ANTIDEPRESSANTS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-12-02 | — | — | US | disclosed |
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5545643-A | USEFUL FOR TREATING DISEASES OF CENTRAL NERVOUS SYSTEM | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-13 | — | — | US | disclosed |
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | disclosed |
| US-5371094-A | Azaheterocyclylmethyl-chromans for treating axiety | BAYER AKTIENGESELLSCHAFT (DE) | 1994-12-06 | — | — | US | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |