Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8860377 | 1.00 | ACE (0.40) | ACEMAPTBRD4MEN1KMT2A | |
| SCHEMBL8860452 | 0.86 | SIGMAR1 (0.39) | ACEMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8860462 | 0.86 | SIGMAR1 (0.39) | ACEMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8870553 | 0.83 | ACE (0.56) | ACEALDH1A1POLBFFAR2LMNA | |
| SCHEMBL8860652 | 0.83 | ACE (0.56) | ACEALDH1A1POLBFFAR2LMNA | |
| SCHEMBL8871032 | 0.78 | ACE (0.46) | ACEFFAR2LMNAHTT | |
| SCHEMBL8870841 | 0.77 | CASR (0.36) | MEN1KMT2AALDH1A1POLBHTT | |
| SCHEMBL8870833 | 0.77 | CASR (0.36) | MEN1KMT2AALDH1A1POLBHTT | |
| SCHEMBL7576506 | 0.75 | USP30 (0.36) | ACEMAPTCYP1A2CYP2C19TSHR | |
| SCHEMBL8144727 | 0.75 | USP30 (0.36) | ACEMAPTCYP1A2CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637602-A | NERVOUS SYSTEM DISORDERS; GASTROINTESTINAL DISORDERS | RHONE-POULENC RORER S.A. (FR) | 1997-06-10 | — | — | US | disclosed |