Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.33 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8860452 | 1.00 | SIGMAR1 (0.39) | SIGMAR1ACEMAPTMEN1ALDH1A1 | |
| SCHEMBL8871032 | 0.92 | ACE (0.46) | SIGMAR1ACE | |
| SCHEMBL8860574 | 0.86 | ACE (0.40) | ACEMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL8860377 | 0.86 | ACE (0.40) | ACEMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL8870833 | 0.82 | CASR (0.36) | MEN1ALDH1A1KMT2APOLB | |
| SCHEMBL8870841 | 0.82 | CASR (0.36) | MEN1ALDH1A1KMT2APOLB | |
| SCHEMBL8829085 | 0.82 | ACE (0.45) | SIGMAR1ACEALDH1A1POLB | |
| SCHEMBL8144727 | 0.81 | USP30 (0.36) | ACEMAPTTSHR | |
| SCHEMBL7576506 | 0.81 | USP30 (0.36) | ACEMAPTTSHR | |
| SCHEMBL8870781 | 0.80 | IDO1 (0.34) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637602-A | NERVOUS SYSTEM DISORDERS; GASTROINTESTINAL DISORDERS | RHONE-POULENC RORER S.A. (FR) | 1997-06-10 | — | — | US | disclosed |