Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 8/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8860452 | 0.92 | SIGMAR1 (0.39) | ACESIGMAR1 | |
| SCHEMBL8860462 | 0.92 | SIGMAR1 (0.39) | ACESIGMAR1 | |
| SCHEMBL8829085 | 0.89 | ACE (0.45) | ACESIGMAR1FFAR2 | |
| SCHEMBL8870576 | 0.87 | HSD17B10 (0.47) | ACESIGMAR1FFAR2 | |
| SCHEMBL8870503 | 0.87 | HSD17B10 (0.47) | ACESIGMAR1FFAR2 | |
| SCHEMBL8871068 | 0.87 | ACE (0.47) | ACESIGMAR1LMNAFFAR2HTT | |
| SCHEMBL8871931 | 0.85 | HTT (0.39) | ACESIGMAR1LMNAFFAR2HTT | |
| SCHEMBL8870842 | 0.82 | ACE (0.39) | ACELMNAFFAR2HTT | |
| SCHEMBL8670628 | 0.82 | SIGMAR1 (0.41) | ACESIGMAR1 | |
| SCHEMBL8870796 | 0.82 | ACE (0.39) | ACELMNAFFAR2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610144-A | CHOLECYSTOKININ OR GASTRIN ANTAGONISTS; NERVOUS SYSTEM AND GASTROINTESTINAL DISORDERS | RHONE-POULENC RORER S.A. (FR) | 1997-03-11 | — | — | US | disclosed |