Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ACE | P12821 | 1/20 | 0.55 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.52 |
| ▸ | FNTA | P49354 | 2/20 | 0.45 |
| ▸ | FNTB | P49356 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL929428 | 1.00 | KDM4E (0.61) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL4990899 | 0.86 | KDM4E (0.61) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL1493214 | 0.86 | KDM4E (0.52) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL10503663 | 0.86 | KDM4E (0.52) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL24308826 | 0.84 | KDM4E (0.59) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL22117302 | 0.84 | KDM4E (0.59) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL26964341 | 0.84 | TGFBR1 (0.52) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL22117303 | 0.84 | KDM4E (0.59) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL367571 | 0.84 | KDM4E (0.59) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL27125557 | 0.84 | TGFBR1 (0.52) | KDM4EMAPTTHRBALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200030268-A1 | AGENTS FOR INCREASING MEIBOMIAN GLAND LIPID SECRETION | Azura Ophthalmics Ltd. (IL) | 2020-01-30 | — | — | US | disclosed |
| US-20090169497-A1 | Treatment and Prevention of Skin Injury Due to Exposure to Ultraviolet Light | THE REGENTS OF THE UNIVERSITY OF COLORADO | 2009-07-02 | — | — | US | disclosed |
| US-5606028-A | Anchimeric radiometal chelating compounds | NEORX CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| US-5202451-A | ANCHIMERIC RADIOMETAL CHELATING COMPOUNDS | NEORX CORPORATION (US) | 1993-04-13 | — | — | US | disclosed |
| US-4925925-A | Radioactive rhenium ligated to 2-hydroxy isobutyric acid and method of use | UNIVERSITY OF CINCINNATI (US) | 1990-05-15 | — | — | US | disclosed |
| US-4839467-A | Radioactive rhenium complexed to 2-hydroxy isobutyric acid | UNIVERSITY OF CINCINNATI (US) | 1989-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200030268-A1 | AGENTS FOR INCREASING MEIBOMIAN GLAND LIPID SECRETION | MGLL, LIPA, LIPE | KDM4E 4740/4885MAPT 3415/4885THRB 1105/4885 |
| US-20090169497-A1 | Treatment and Prevention of Skin Injury Due to Exposure to Ultraviolet Light | MGMT, S100A6, S100A9 | KDM4E 4457/4885MAPT 2693/4885THRB 3720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.