Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.50 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026456 | 0.90 | MGLL (0.50) | MAOAMAOBDRD2DRD4DRD3 | |
| SCHEMBL3028864 | 0.90 | MGLL (0.50) | MAOAMAOBDRD2DRD4DRD3 | |
| SCHEMBL8862906 | 0.90 | MGLL (0.50) | MAOAMAOBDRD2DRD4DRD3 | |
| SCHEMBL7632387 | 0.88 | DRD2 (0.51) | MAOAMAOBDRD2DRD4DRD3 | |
| SCHEMBL27400247 | 0.87 | CYP4F2 (0.66) | MAOAMAOBBCHECYP4F2CYP4A11 | |
| SCHEMBL9172207 | 0.85 | PPARA (0.50) | KCNH2 | |
| SCHEMBL9255242 | 0.85 | CYP2D6 (0.55) | KCNH2 | |
| SCHEMBL27996289 | 0.85 | FFAR1 (0.56) | MAOAMAOBKCNH2BCHECYP4F2 | |
| SCHEMBL7630360 | 0.85 | DRD2 (0.51) | MAOAMAOBDRD2DRD4DRD3 | |
| SCHEMBL7349698 | 0.84 | PPARA (0.56) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1038586-C | Pyrazine derivatives and process for preparing same | OTSUKA PHARMA CO LTD (JP) | 1998-06-03 | — | — | CN | disclosed |
| US-5607934-A | PREVENTING AND TREATING DISEASES CAUSED BY SUPEROXIDE RADICALS, NEPHRITIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| CN-1112364-A | Piperazine derivatives and salts thereof | OTSUKA PHARMA CO LTD (JP) | 1995-11-22 | — | — | CN | disclosed |
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0659182-A1 | PIPERAZINE DERIVATIVES AND SALTS THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-06-28 | — | — | EP | disclosed |
| EP-0511879-B1 | Pyrazine derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-03-22 | — | — | EP | disclosed |
| WO-1995002593-A1 | PIPERAZINE DERIVATIVES AND SALTS THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-01-26 | — | — | WO | disclosed |
| CN-1067053-A | Pyrazines derivatives and preparation method thereof | OTSUKA PHARMA CO LTD (JP) | 1992-12-16 | — | — | CN | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |