Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL768782 | 0.91 | AKR1B1 (0.40) | KDM1AAKR1B1 | |
| SCHEMBL7609559 | 0.79 | KDM1A (0.39) | TSHRTDP1KDM1AMAOBHTR2A | |
| SCHEMBL6902549 | 0.76 | SIGMAR1 (0.43) | TSHRTDP1KDM1AMAOBHDAC9 | |
| SCHEMBL8865262 | 0.74 | KDM1A (0.47) | KDM1AAKR1B1 | |
| SCHEMBL742433 | 0.74 | MAPK1 (0.38) | TSHRKDM1AMAPK1SMN1; SMN2 | |
| SCHEMBL9531758 | 0.70 | TSHR (0.40) | TSHRTDP1KDM1AMAOBHTR2A | |
| SCHEMBL5796055 | 0.70 | HDAC9 (0.50) | TSHRTDP1KDM1AMAOBHDAC9 | |
| SCHEMBL3053835 | 0.70 | KDM1A (0.43) | TSHRTDP1KDM1AMAOBHTR2A | |
| SCHEMBL19130584 | 0.70 | HDAC9 (0.50) | TSHRTDP1KDM1AMAOBHDAC9 | |
| SCHEMBL5871752 | 0.68 | CYP3A4 (0.57) | TSHRTDP1KDM1AMAOBHDAC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1054376-C | Substituted 1H-imidazoles | UCB SA (BE) | 2000-07-12 | — | — | CN | disclosed |
| US-5658938-A | HYPOTENSIVE AGENT, ANTIISCHMIC AGENTS | U C B S.A. (BE) | 1997-08-19 | — | — | US | disclosed |
| CN-1133837-A | Substituted 1H-imidazoles | UCB SA (BE) | 1996-10-23 | — | — | CN | disclosed |
| EP-0717037-A1 | Substituted 1H-imidazoles having alpha 2-agonistic and alpha 1-antagonistic activity | U C B, S.A. (BE) | 1996-06-19 | — | — | EP | disclosed |