Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.38 |
| ▸ | MMP2 | P08253 | 6/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865286 | 0.89 | SIRT2 (0.39) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL8865728 | 0.89 | KMT2A (0.38) | SIRT2 | |
| SCHEMBL8865570 | 0.86 | SIGMAR1 (0.42) | SIRT2 | |
| SCHEMBL9518110 | 0.85 | FLT3 (0.39) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL1736246 | 0.85 | CYP11B1 (0.37) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL8865969 | 0.84 | SIRT2 (0.34) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL8986522 | 0.84 | SIRT2 (0.40) | SIRT2 | |
| SCHEMBL10457235 | 0.84 | SIRT2 (0.37) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL8865406 | 0.83 | ADRB2 (0.43) | — | |
| SCHEMBL8865051 | 0.81 | ADRB2 (0.37) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717037-A1 | Substituted 1H-imidazoles having alpha 2-agonistic and alpha 1-antagonistic activity | U C B, S.A. (BE) | 1996-06-19 | — | — | EP | claimed |
| CN-1054376-C | Substituted 1H-imidazoles | UCB SA (BE) | 2000-07-12 | — | — | CN | disclosed |
| US-5658938-A | HYPOTENSIVE AGENT, ANTIISCHMIC AGENTS | U C B S.A. (BE) | 1997-08-19 | — | — | US | disclosed |
| CN-1133837-A | Substituted 1H-imidazoles | UCB SA (BE) | 1996-10-23 | — | — | CN | disclosed |
| EP-0717037-A1 | Substituted 1H-imidazoles having alpha 2-agonistic and alpha 1-antagonistic activity | U C B, S.A. (BE) | 1996-06-19 | — | — | EP | disclosed |