Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10457235 | 0.93 | SIRT2 (0.37) | FLT3TYRO3MERTKGAS6SIRT2 | |
| SCHEMBL5060964 | 0.87 | LMNA (0.40) | FLT3TYRO3MERTKGAS6SIRT2 | |
| SCHEMBL1736246 | 0.86 | CYP11B1 (0.37) | FLT3TYRO3MERTKGAS6SIRT2 | |
| SCHEMBL8865638 | 0.85 | FAAH (0.38) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL8865969 | 0.83 | SIRT2 (0.34) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL31646315 | 0.82 | CYP11B1 (0.38) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL6363934 | 0.81 | SIRT2 (0.38) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL8865051 | 0.80 | ADRB2 (0.37) | SIRT2 | |
| SCHEMBL8865286 | 0.80 | SIRT2 (0.39) | KDM4EALDH1A1SIRT2CYP11B1CYP11B2 | |
| SCHEMBL1039275 | 0.80 | CYP11B1 (0.41) | FLT3TYRO3MERTKGAS6SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269599-B1 | Substituted 1H-imidazoles | UCB SA (BE) | 1993-12-15 | — | — | EP | disclosed |
| US-4814343-A | ANTIISCHEMIC | U C B, S.A. (BE) | 1989-03-21 | — | — | US | disclosed |
| EP-0269599-A2 | Substituted 1H-imidazoles | U C B, S.A. (BE) | 1988-06-01 | — | — | EP | disclosed |