Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865638 | 0.89 | FAAH (0.38) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL8865728 | 0.87 | KMT2A (0.38) | SIRT2TAAR1ALDH1A1CHRM2CHRM3 | |
| SCHEMBL8865570 | 0.86 | SIGMAR1 (0.42) | SIRT2TAAR1CHRM2CHRM3 | |
| SCHEMBL8986522 | 0.85 | SIRT2 (0.40) | SIRT2ALDH1A1KDM4E | |
| SCHEMBL8865406 | 0.82 | ADRB2 (0.43) | ALDH1A1KDM4E | |
| SCHEMBL8865969 | 0.81 | SIRT2 (0.34) | SIRT2TAAR1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9518110 | 0.80 | FLT3 (0.39) | SIRT2ALDH1A1KDM4ECYP11B1CYP11B2 | |
| SCHEMBL10457235 | 0.79 | SIRT2 (0.37) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL1736246 | 0.77 | CYP11B1 (0.37) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL8865051 | 0.76 | ADRB2 (0.37) | SIRT2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658938-A | HYPOTENSIVE AGENT, ANTIISCHMIC AGENTS | U C B S.A. (BE) | 1997-08-19 | — | — | US | disclosed |
| EP-0717037-A1 | Substituted 1H-imidazoles having alpha 2-agonistic and alpha 1-antagonistic activity | U C B, S.A. (BE) | 1996-06-19 | — | — | EP | disclosed |