Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.33 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.33 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865654 | 0.84 | SLC6A2 (0.35) | OPRM1ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL8865718 | 0.81 | SRD5A1 (0.39) | HTR2COPRM1ADRA2AADRA1AADRA1D | |
| SCHEMBL7608212 | 0.81 | ADRA2A (0.40) | HTR2COPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL8865945 | 0.81 | HTR1A (0.41) | HTR1A | |
| SCHEMBL769063 | 0.79 | ADRA1A (0.55) | OPRM1ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL8865200 | 0.78 | ESR1 (0.44) | ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL8866107 | 0.78 | HTR1A (0.34) | HTR2COPRM1ADRA2AADRA1AADRA1D | |
| SCHEMBL7607563 | 0.76 | HTR1A (0.39) | HTR2CHTR2BHTR1A | |
| SCHEMBL8865117 | 0.76 | SRD5A1 (0.39) | OPRM1ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL30543392 | 0.75 | ADRA2A (0.58) | P2RX7ADRA2AADRA1AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658938-A | HYPOTENSIVE AGENT, ANTIISCHMIC AGENTS | U C B S.A. (BE) | 1997-08-19 | — | — | US | disclosed |
| EP-0717037-A1 | Substituted 1H-imidazoles having alpha 2-agonistic and alpha 1-antagonistic activity | U C B, S.A. (BE) | 1996-06-19 | — | — | EP | disclosed |