Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867946 | 0.87 | MAPT (0.58) | XDHKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL8866993 | 0.86 | XDH (1.00) | XDHKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL8867366 | 0.81 | SMN1; SMN2 (0.72) | XDHKMT2ACYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL23794689 | 0.80 | KMT2A (0.80) | XDHKMT2ASMN1; SMN2RAB9APOLB | |
| SCHEMBL3615192 | 0.79 | SMN1; SMN2 (0.68) | XDHKMT2ACYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL8866740 | 0.78 | SMN1; SMN2 (0.71) | XDHKMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL2069278 | 0.77 | RAB9A (1.00) | XDHKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL4200739 | 0.75 | MEN1 (0.69) | KMT2AMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3434172 | 0.74 | SMN1; SMN2 (0.74) | XDHKMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL8867692 | 0.73 | XDH (0.74) | XDHKMT2AMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614520-A | 2-arylthiazole derivatives and pharmaceutical composition thereof | TEIJIN LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0513379-B1 | 2-ARYLTHIAZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | TEIJIN LTD (JP) | 1996-09-11 | — | — | EP | disclosed |
| EP-0513379-A1 | 2-ARYLTHIAZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | TEIJIN LIMITED (JP) | 1992-11-19 | — | — | EP | disclosed |