Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31090163 | 0.90 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1HTTLMNAGAA | |
| SCHEMBL8867665 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1HTTLMNAGAA | |
| SCHEMBL30875697 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1HTTLMNAGAA | |
| SCHEMBL1667910 | 0.87 | TTR (0.68) | SMN1; SMN2ALDH1A1HTTLMNAGAA | |
| SCHEMBL8973887 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1HTTLMNAGAA | |
| SCHEMBL8867003 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1HTTLMNAGAA | |
| SCHEMBL2742574 | 0.84 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1HTTLMNAGAA | |
| SCHEMBL7317606 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1HTTLMNAGAA | |
| SCHEMBL30135880 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1HTTLMNAGAA | |
| SCHEMBL3720228 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1HTTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888125-B | TYK2 inhibitor and application thereof | 上海齐鲁制药研究中心有限公司 | 2024-04-12 | — | — | CN | disclosed |
| EP-4319756-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-116888125-A | TYK2 inhibitor and application thereof | 上海齐鲁制药研究中心有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022213980-A1 | TYK2 INHIBITOR AND USE THEREOF | 上海齐鲁制药研究中心有限公司 | 2022-10-13 | — | — | WO | disclosed |
| WO-2022217276-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-10-13 | — | — | WO | disclosed |
| EP-3763711-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS | Allinky Biopharma (ES) | 2021-01-13 | — | — | EP | disclosed |
| US-5686484-A | ANTHELMINTICS, ACARICIDES, INSECTICIDES | SANKYO CO., LTD. (JP) | 1997-11-11 | — | — | US | disclosed |