SCHEMBL8867045

SCHEMBL8867045

O=C(Nc1cccc(/C=C/CO)c1)c1ccncc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 4/20 0.59
SMN1; SMN2 Q16637 2/20 0.57
PKM P14618 1/20 0.54
HTT P42858 1/20 0.54
KCNK9 Q9NPC2 2/20 0.53
SNCA P37840 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.50
GAA P10253 1/20 0.50
LMNA P02545 3/20 0.49
KMT2A Q03164 2/20 0.49
MEN1 O00255 1/20 0.49
POLB P06746 2/20 0.48
MAPK1 P28482 1/20 0.48
KDR P35968 1/20 0.47
JAK2 O60674 1/20 0.47
TYK2 P29597 1/20 0.47
KDM4E B2RXH2 2/20 0.46
PSMD14 O00487 1/20 0.46
MAPT P10636 1/20 0.46
THRB P10828 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8867040 0.90 KCNK3 (0.59) KCNK3SMN1; SMN2PKMHTTKCNK9
SCHEMBL8867042 0.90 KCNK3 (0.59) KCNK3SMN1; SMN2PKMHTTKCNK9
SCHEMBL8868839 0.86 KCNK3 (0.62) KCNK3SMN1; SMN2PKMHTTL3MBTL1
SCHEMBL8867781 0.84 HDAC3 (0.54) KCNK3SMN1; SMN2PKMKCNK9SNCA
SCHEMBL8867825 0.84 SNCA (0.68) KCNK3SMN1; SMN2PKMKCNK9SNCA
SCHEMBL8867002 0.84 PKM (0.54) KCNK3SMN1; SMN2PKMKCNK9SNCA
SCHEMBL8866604 0.84 L3MBTL1 (0.70) KCNK3PKMKCNK9SNCAL3MBTL1
SCHEMBL8868806 0.82 RAB9A (0.54) SMN1; SMN2PKMSNCAL3MBTL1LMNA
SCHEMBL8867898 0.82 RAB9A (0.56) SMN1; SMN2PKMKCNK9SNCAL3MBTL1
SCHEMBL15652762 0.82 KCNK3 (0.68) KCNK3SMN1; SMN2PKMHTTKCNK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5686484-A ANTHELMINTICS, ACARICIDES, INSECTICIDES SANKYO CO., LTD. (JP) 1997-11-11 US disclosed