Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868704 | 0.95 | P4HTM (0.48) | PPARANPC1RAB9AP4HTMSMN1; SMN2 | |
| SCHEMBL8868009 | 0.92 | P4HTM (0.46) | PPARAFLT1FLT4KDRNPC1 | |
| SCHEMBL7870556 | 0.91 | PPARA (0.46) | PPARAFLT1FLT4KDRNPC1 | |
| SCHEMBL8867585 | 0.90 | NLRP3 (0.57) | MAPTLMNANLRP3CYP3A4CYP2C9 | |
| SCHEMBL8870501 | 0.89 | P4HTM (0.43) | PPARAFLT1FLT4KDRNPC1 | |
| SCHEMBL8868612 | 0.89 | P4HTM (0.45) | PPARANPC1RAB9AP4HTMSMN1; SMN2 | |
| SCHEMBL8870423 | 0.87 | LMNA (0.48) | PPARAP4HTMSMN1; SMN2MAPTLMNA | |
| SCHEMBL8869128 | 0.87 | PPARA (0.50) | PPARAFLT1FLT4KDRNPC1 | |
| SCHEMBL8869577 | 0.86 | EGFR (0.53) | PPARAFLT1FLT4KDRNPC1 | |
| SCHEMBL8869604 | 0.86 | EGFR (0.53) | PPARAFLT1FLT4KDRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |