Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870501 | 0.94 | P4HTM (0.43) | P4HTMRAB9ANPC1ALDH1A1GAA | |
| SCHEMBL8868704 | 0.92 | P4HTM (0.48) | P4HTMRAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL8868009 | 0.91 | P4HTM (0.46) | P4HTMRAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL7870468 | 0.90 | ALDH1A1 (0.43) | P4HTMRAB9ANPC1ALDH1A1GAA | |
| SCHEMBL8868529 | 0.89 | PPARA (0.49) | P4HTMRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL8868453 | 0.89 | P4HTM (0.47) | P4HTMRAB9ANPC1ALDH1A1GAA | |
| SCHEMBL8869090 | 0.88 | ALDH1A1 (0.51) | P4HTMRAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL9143419 | 0.85 | P4HTM (0.48) | P4HTMRAB9ANPC1ALDH1A1GAA | |
| SCHEMBL9139777 | 0.85 | P4HTM (0.49) | P4HTMRAB9AALDH1A1GAAMEN1 | |
| SCHEMBL8867585 | 0.84 | NLRP3 (0.57) | ALDH1A1MEN1KMT2AHIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |