Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 10/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 10/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870069 | 0.91 | P4HTM (0.57) | P4HTMBCL2L1MCL1EGFR | |
| SCHEMBL8867590 | 0.90 | P4HTM (0.72) | P4HTMEGFR | |
| SCHEMBL8869710 | 0.89 | P4HTM (0.56) | P4HTMBCL2L1MCL1EGFR | |
| SCHEMBL8868775 | 0.88 | P4HTM (0.53) | P4HTMBCL2L1MCL1 | |
| SCHEMBL8868876 | 0.87 | P4HTM (0.72) | P4HTMEGFRMMP2CA1CA2 | |
| SCHEMBL8868123 | 0.87 | BCL2L1 (0.49) | P4HTMBCL2L1MCL1MMP2MMP13 | |
| SCHEMBL8870946 | 0.85 | ALDH1A1 (0.55) | P4HTM | |
| SCHEMBL8870133 | 0.84 | P4HTM (0.56) | P4HTMBCL2L1MCL1EGFRMMP2 | |
| SCHEMBL8867851 | 0.84 | P4HTM (0.53) | P4HTMEGFRMMP2MMP13MMP14 | |
| SCHEMBL8869095 | 0.84 | ALKBH2 (0.57) | BCL2L1MCL1MMP2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |