Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 10/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 9/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868915 | 0.92 | P4HTM (0.66) | P4HTMEGFR | |
| SCHEMBL8868775 | 0.91 | P4HTM (0.53) | P4HTMMCL1BCL2L1NPC1RAB9A | |
| SCHEMBL8869092 | 0.91 | P4HTM (0.59) | P4HTMMCL1BCL2L1EGFR | |
| SCHEMBL8869962 | 0.88 | P4HTM (0.58) | P4HTMNPC1RAB9ASMN1; SMN2EGFR | |
| SCHEMBL8870475 | 0.87 | RAB9A (0.54) | P4HTMMCL1BCL2L1NPC1RAB9A | |
| SCHEMBL8869822 | 0.86 | P4HTM (0.54) | P4HTMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8869178 | 0.86 | P4HTM (0.54) | P4HTMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7869459 | 0.85 | MCL1 (0.52) | P4HTMMCL1BCL2L1CYP1A2CYP2C9 | |
| SCHEMBL8868425 | 0.85 | P4HTM (0.53) | P4HTMMCL1BCL2L1NPC1RAB9A | |
| SCHEMBL9140706 | 0.85 | P4HTM (0.64) | P4HTMMCL1BCL2L1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |