Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 5/20 | 0.39 |
| ▸ | THRB | P10828 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KIF20A | O95235 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869778 | 0.85 | SCN9A (0.45) | SCN9ANR4A2MTNR1AMTNR1BTHRA | |
| SCHEMBL8868878 | 0.85 | MTNR1A (0.50) | SCN9ANR4A2MTNR1AMTNR1BTHRA | |
| SCHEMBL6226884 | 0.80 | LMNA (0.47) | CYP3A4DYRK1ALMNATDP1 | |
| SCHEMBL6226878 | 0.80 | LMNA (0.47) | CYP3A4DYRK1ALMNATDP1 | |
| SCHEMBL8869454 | 0.79 | LTA4H (0.57) | CYP3A4MTNR1AMTNR1BTDP1 | |
| SCHEMBL8870222 | 0.79 | MTNR1A (0.43) | SCN9ACYP3A4NR4A2MTNR1AMTNR1B | |
| SCHEMBL9210783 | 0.78 | LMNA (0.48) | MTNR1AMTNR1BKIF20ADYRK1ALMNA | |
| SCHEMBL28007326 | 0.77 | MAP2K1 (0.47) | CYP3A4MTNR1ATP53MAPT | |
| SCHEMBL9204210 | 0.76 | LMNA (0.46) | NR4A2MTNR1AMTNR1BTHRATHRB | |
| SCHEMBL8883939 | 0.73 | TACR1 (0.41) | MTNR1AMTNR1BTHRATHRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637593-A | MIGRAINE; HYPOTENSIVE AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1997-06-10 | — | — | US | disclosed |