SCHEMBL8869778

SCHEMBL8869778

Cc1ccc(Oc2ccc3[nH]cc(C(C)NC(=O)OC(C)(C)C)c3c2)cc1

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 2/20 0.45
THRA P10827 9/20 0.43
THRB P10828 9/20 0.43
MTNR1A P48039 1/20 0.43
MTNR1B P49286 1/20 0.43
MAPT P10636 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
TACR1 P25103 1/20 0.41
NR4A2 P43354 1/20 0.40
TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8868878 0.91 MTNR1A (0.50) SCN9ATHRATHRBMTNR1AMTNR1B
SCHEMBL8869461 0.85 SCN9A (0.44) SCN9ATHRATHRBMTNR1AMTNR1B
SCHEMBL25553501 0.81 MAPT (0.44) SCN9ATHRATHRBMTNR1AMTNR1B
SCHEMBL8870222 0.79 MTNR1A (0.43) SCN9ATHRATHRBMTNR1AMTNR1B
SCHEMBL8883939 0.77 TACR1 (0.41) THRATHRBMTNR1AMTNR1BMAPT
SCHEMBL8869773 0.77 LTA4H (0.59) MTNR1AMTNR1BMAPTTP53
SCHEMBL9211145 0.75 HTR2B (0.50) THRATHRBMTNR1AMTNR1BMAPT
SCHEMBL9213440 0.73 HTR2A (0.45) THRATHRBMTNR1AMTNR1BMAPT
SCHEMBL24208355 0.72 SCN9A (0.49) SCN9AMAPTSMN1; SMN2
SCHEMBL30391992 0.72 SCN9A (0.49) SCN9AMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5637593-A MIGRAINE; HYPOTENSIVE AGENTS SMITHKLINE BEECHAM PLC (GB) 1997-06-10 US disclosed
EP-0674619-A1 TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-10-04 EP disclosed
WO-1994014770-A1 TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-07-07 WO disclosed