Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869014 | 0.92 | P4HTM (0.54) | HTTP4HTMALDH1A1HDAC8HDAC6 | |
| SCHEMBL8870098 | 0.91 | RAB9A (0.54) | HTTP4HTMALDH1A1GAAHSD17B10 | |
| SCHEMBL8870157 | 0.91 | P4HTM (0.52) | HTTP4HTMALDH1A1HDAC8HDAC6 | |
| SCHEMBL9139389 | 0.90 | P4HTM (0.67) | HTTP4HTMALDH1A1GAAHSD17B10 | |
| SCHEMBL8869077 | 0.90 | P4HTM (0.51) | HTTP4HTMALDH1A1HDAC8HDAC6 | |
| SCHEMBL8869181 | 0.89 | P4HTM (0.54) | P4HTMALDH1A1GAAHDAC8HDAC6 | |
| SCHEMBL8869795 | 0.87 | P4HTM (0.51) | HTTP4HTMHSD17B10POLBNAMPT | |
| SCHEMBL8869289 | 0.87 | HTT (0.53) | HTTP4HTMALDH1A1GAAHSD17B10 | |
| SCHEMBL8869079 | 0.87 | RAB9A (0.53) | P4HTMRAB9APOLB | |
| SCHEMBL9137770 | 0.86 | HTT (0.57) | HTTP4HTMALDH1A1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |