Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 10/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870698 | 1.00 | NR1H2 (0.40) | NR1H2NR1H3GPR119ABCB1RXRA | |
| SCHEMBL8671973 | 0.80 | NR1H2 (0.35) | NR1H2NR1H3GPR119ABCB1MEN1 | |
| SCHEMBL20835920 | 0.74 | ABCB1 (0.46) | NR1H2NR1H3GPR119ABCB1RXRA | |
| SCHEMBL8870879 | 0.73 | GPR119 (0.46) | GPR119ABCB1LMNA | |
| SCHEMBL8870873 | 0.73 | GPR119 (0.46) | GPR119ABCB1LMNA | |
| SCHEMBL23452424 | 0.71 | HTRA1 (0.49) | NR1H2NR1H3GPR119RXRALMNA | |
| SCHEMBL30882336 | 0.71 | HTRA1 (0.49) | NR1H2NR1H3GPR119RXRALMNA | |
| SCHEMBL25364354 | 0.71 | HTRA1 (0.49) | NR1H2NR1H3GPR119RXRALMNA | |
| SCHEMBL29035142 | 0.71 | HTRA1 (0.49) | NR1H2NR1H3GPR119RXRALMNA | |
| SCHEMBL25366199 | 0.71 | HTRA1 (0.49) | NR1H2NR1H3GPR119RXRALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610144-A | CHOLECYSTOKININ OR GASTRIN ANTAGONISTS; NERVOUS SYSTEM AND GASTROINTESTINAL DISORDERS | RHONE-POULENC RORER S.A. (FR) | 1997-03-11 | — | — | US | disclosed |