Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.57 |
| ▸ | MAOB | P27338 | 6/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29913658 | 0.88 | HSD17B3 (0.58) | MAOAMAOBPTGS1KDM4EALDH1A1 | |
| SCHEMBL10794446 | 0.84 | MAOA (0.62) | MAOAMAOBPTGS1KDM4EALDH1A1 | |
| SCHEMBL10419623 | 0.82 | MAOA (0.57) | MAOAMAOBSMN1; SMN2CA2FLT3 | |
| SCHEMBL11617055 | 0.81 | MAOA (0.62) | MAOAMAOBPTGS1KDM4EALDH1A1 | |
| SCHEMBL15065807 | 0.80 | MAOB (0.56) | MAOAMAOBKDM4EALDH1A1LMNA | |
| SCHEMBL8870655 | 0.79 | GPR55 (0.64) | MAOAMAOBKDM4EALDH1A1GAA | |
| SCHEMBL27380273 | 0.78 | MAOA (0.56) | MAOAMAOBPTGS1KDM4EALDH1A1 | |
| SCHEMBL12414854 | 0.77 | MAOA (0.58) | MAOAMAOBPTGS1KDM4EALDH1A1 | |
| SCHEMBL10791744 | 0.74 | HSD17B3 (0.74) | MAOAMAOBPTGS1KDM4EALDH1A1 | |
| SCHEMBL5306505 | 0.73 | CA12 (0.65) | MAOAMAOBPTGS1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607928-A | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives | ZENECA LIMITED (GB) | 1997-03-04 | — | — | US | disclosed |
| EP-0695753-A1 | Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use | ZENECA LIMITED (GB) | 1996-02-07 | — | — | EP | disclosed |