Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.75 |
| ▸ | ACHE | P22303 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 10/20 | 0.58 |
| ▸ | MAOB | P27338 | 10/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28532367 | 0.87 | KDM4E (0.62) | KDM4EACHEMAOAMAOBSIGMAR1 | |
| 7-Methoxychromone SCHEMBL1854902 | 0.86 | KDM4E (1.00) | KDM4EMAOAMAOBNPC1ALDH1A1 | |
| 7-Methoxychromone SCHEMBL31260290 | 0.86 | KDM4E (1.00) | KDM4EMAOAMAOBNPC1ALDH1A1 | |
| SCHEMBL15201132 | 0.82 | ACHE (0.64) | KDM4EACHEMAOAMAOBSIGMAR1 | |
| 7-Methoxychromone SCHEMBL28430247 | 0.80 | KDM4E (0.88) | KDM4EMAOAMAOBNPC1ALDH1A1 | |
| SCHEMBL2976539 | 0.79 | SIGMAR1 (0.73) | ACHEMAOAMAOBSIGMAR1 | |
| SCHEMBL28739751 | 0.78 | ACHE (0.59) | ACHEMAOAMAOBSIGMAR1 | |
| 7-Methoxychromone SCHEMBL28423141 | 0.78 | KDM4E (0.82) | KDM4EMAOAMAOBSIGMAR1ALDH1A1 | |
| SCHEMBL28124918 | 0.77 | KDM4E (0.77) | KDM4EMAOAMAOBNPC1ALDH1A1 | |
| SCHEMBL27767737 | 0.77 | MAOB (0.68) | ACHEMAOAMAOBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107405337-B | Substituted chromans and methods of use | 艾伯维公司 | 2021-02-09 | — | — | CN | disclosed |
| EP-3212189-B1 | SUBSTITUTED CHROMANES AND METHOD OF USE | ABBVIE OVERSEAS SÀ RL (LU) | 2020-09-09 | — | — | EP | disclosed |
| US-20190127356-A1 | Substituted Chromanes and Method of Use | ABBVIE OVERSEAS S.Á.R.L. (LU) | 2019-05-02 | — | — | US | disclosed |
| US-20170190693-A1 | SUBSTITUTED CHROMANES AND METHOD OF USE | ABBVIE S À R L (LU) | 2017-07-06 | — | — | US | disclosed |
| US-9642831-B2 | Substituted chromanes and method of use | ABBVIE S.Á.R.L. (LU) | 2017-05-09 | — | — | US | disclosed |
| US-20160120841-A1 | SUBSTITUTED CHROMANES AND METHOD OF USE | ABBVIE GLOBAL LIMITED (BM) | 2016-05-05 | — | — | US | disclosed |
| US-5607928-A | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives | ZENECA LIMITED (GB) | 1997-03-04 | — | — | US | disclosed |
| EP-0695753-A1 | Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use | ZENECA LIMITED (GB) | 1996-02-07 | — | — | EP | disclosed |
| US-4777168-A | ANTISECRETORY, ANTIULCER AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1988-10-11 | — | — | US | disclosed |
| US-4722925-A | ANTIULCER AGENTS, GASTROINTESTINAL DISORDERS | RORER PHARMACEUTICAL CORPORATION (US) | 1988-02-02 | — | — | US | disclosed |
| EP-0198918-A4 | BICYCLIC BENZO-OXY HETEROCYCLIC ETHERS AND THIOETHERS AS H 2?-RECEPTORS ANTAGONISTS. | RORER INTERNAT OVERSEAS INC (US) | 1987-08-10 | — | — | EP | disclosed |
| US-4668673-A | ANTISECRETORY, ANTIULCER, ANTACIDS | WILLIAM H. RORER, INC. (US) | 1987-05-26 | — | — | US | disclosed |
| EP-0198918-A1 | BICYCLIC BENZO-OXY HETEROCYCLIC ETHERS AND THIOETHERS AS H 2?-RECEPTORS ANTAGONISTS | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4612309-A | Antisecretory bicyclic benzo-oxy heterocyclic ethers and thioethers | WILLIAM H. RORER, INC. (US) | 1986-09-16 | — | — | US | disclosed |
| WO-1986002550-A1 | BICYCLIC BENZO-OXY HETEROCYCLIC ETHERS AND THIOETHERS AS H2-RECEPTORS ANTAGONISTS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1986-05-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190693-A1 | SUBSTITUTED CHROMANES AND METHOD OF USE | CFTR, CHRM3, CHRM2 | KDM4E 4039/4885ACHE 713/4885MAOA 3482/4885 |
| US-20160120841-A1 | SUBSTITUTED CHROMANES AND METHOD OF USE | CFTR, CHRM3, CHRM2 | KDM4E 4039/4885ACHE 713/4885MAOA 3482/4885 |
| US-20190127356-A1 | Substituted Chromanes and Method of Use | CFTR, CHRM3, CHRM2 | KDM4E 4039/4885ACHE 713/4885MAOA 3482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.