SCHEMBL8871808

SCHEMBL8871808

CCOC(=O)C(F)C1(c2ccc(F)cc2F)CO1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.38
MAPT P10636 3/20 0.38
POLB P06746 2/20 0.38
ALDH1A1 P00352 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
HCAR3 P49019 1/20 0.37
HCAR2 Q8TDS4 1/20 0.37
PKM P14618 1/20 0.36
MAPK14 Q16539 1/20 0.35
HDAC4 P56524 1/20 0.35
THRB P10828 1/20 0.35
TSHR P16473 1/20 0.34
NPC1 O15118 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
USP2 O75604 1/20 0.34
TP53 P04637 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8871320 0.80 HCAR3 (0.38) HCAR3HCAR2HDAC4
SCHEMBL8700904 0.74 HCAR3 (0.44) ALDH1A1HCAR3HCAR2PKMHDAC4
SCHEMBL8551674 0.74 HCAR3 (0.44) ALDH1A1HCAR3HCAR2PKMHDAC4
SCHEMBL8871864 0.73 MAPT (0.42) RAB9AMAPTPOLBALDH1A1TDP1
SCHEMBL7808769 0.73 MAPT (0.39) RAB9AMAPTPOLBALDH1A1TDP1
SCHEMBL939090 0.73 HCAR3 (0.38) RAB9AMAPTPOLBALDH1A1TDP1
SCHEMBL1828149 0.73 HCAR3 (0.38) RAB9AMAPTPOLBALDH1A1TDP1
SCHEMBL20970623 0.73 HCAR3 (0.38) RAB9AMAPTPOLBALDH1A1TDP1
SCHEMBL7684896 0.73 HCAR3 (0.38) RAB9AMAPTPOLBALDH1A1TDP1
SCHEMBL1828008 0.73 HCAR3 (0.38) RAB9AMAPTPOLBALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5605921-A Triazole derivatives and salts thereof, and antifungal agent containing the same TOYAMA CHEMICAL CO., LTD. (JP) 1997-02-25 US disclosed
US-5366989-A Triazole derivatives and salts thereof and antifungal agent containing the same TOYAMA CHEMICAL CO., LTD. (JP) 1994-11-22 US disclosed
EP-0546529-A1 Triazole derivatives and salts thereof, processes for producing the same, and antifungal agent containing the same TOYAMA CHEMICAL CO., LTD. (JP) 1993-06-16 EP disclosed