Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871221 | 0.76 | MEN1 (0.47) | ALDH1A1MEN1HPGDKMT2AKDM4E | |
| SCHEMBL8873578 | 0.73 | BCHE (0.47) | ALDH1A1ACHEOPRM1OPRD1OPRK1 | |
| SCHEMBL8871835 | 0.73 | ALDH1A1 (0.51) | NPSR1ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL5175960 | 0.71 | FAAH (0.55) | RAB9ABCHEMAOBKDM4E | |
| SCHEMBL8539481 | 0.70 | ACHE (0.42) | ALDH1A1ACHEOPRM1OPRD1OPRK1 | |
| SCHEMBL8871798 | 0.70 | KDM4E (0.45) | GAARAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8544287 | 0.69 | HRH3 (0.45) | ALDH1A1ACHEOPRM1OPRK1HPGD | |
| SCHEMBL8544368 | 0.68 | ACHE (0.40) | ALDH1A1ACHEOPRM1OPRD1OPRK1 | |
| SCHEMBL31029109 | 0.68 | OPRK1 (0.56) | GAANPSR1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6627559 | 0.68 | GAA (0.62) | GAANPSR1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591856-A | CHEMICAL INTERMEDIATES, TREATMENT OF ALZHEIMER'S DISEASE | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5554750-A | TO RELIEVE MEMORY DYSFUNCTIONS; TREATMENT OF ALZHEMER*S | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-09-10 | — | — | US | disclosed |
| EP-0671388-A1 | (Pyrrolidinyl)phenyl carbamates and intermediate compounds, processes for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5405845-A | Administering to relieve memory dysfunction; treatment of Alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-04-11 | — | — | US | disclosed |
| US-5338739-A | Memory dysfunction relieving compounds | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-08-16 | — | — | US | disclosed |