Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 8/20 | 0.41 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | RAC1 | P63000 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871314 | 0.87 | HTR1A (0.56) | DRD1DRD2DRD3DRD5HTR1A | |
| SCHEMBL8871646 | 0.77 | TSHR (0.39) | DRD1DRD2HTR1A | |
| SCHEMBL10535627 | 0.66 | DRD1 (0.64) | DRD1DRD2RAC1DRD3DRD5 | |
| Bisnorargemonine SCHEMBL29617591 | 0.64 | HTR1A (0.73) | DRD1DRD2DRD3DRD5MAOA | |
| SCHEMBL20646128 | 0.62 | FYN (0.44) | DRD2DRD3MAOAFYN | |
| SCHEMBL8276783 | 0.62 | FYN (0.56) | DRD2DRD3MAOAFYN | |
| SCHEMBL21637895 | 0.62 | NOTUM (0.44) | — | |
| SCHEMBL5131200 | 0.61 | MAOA (0.46) | DRD2DRD3MAOA | |
| SCHEMBL29803390 | 0.61 | ACE (0.38) | — | |
| SCHEMBL22462292 | 0.61 | ACE (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5648359-A | ESCHSCHOLTZINE AND DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-07-15 | — | — | US | disclosed |
| EP-0663210-A2 | Tumor necrosis factor production inhibitors | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-07-19 | — | — | EP | disclosed |