Bisnorargemonine

Bisnorargemonine

SCHEMBL29617591

COc1cc2c(cc1O)[C@@H]1Cc3cc(O)c(OC)cc3C(C2)N1C

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 2/20 0.73
DRD1 P21728 13/20 0.60
DRD2 P14416 11/20 0.60
DRD3 P35462 2/20 0.60
DRD5 P21918 1/20 0.60
MAOA P21397 1/20 0.50
KDM4E B2RXH2 1/20 0.50
LMNA P02545 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CASP1 P29466 1/20 0.50
CYP2C19 P33261 1/20 0.50
APAF1 O14727 1/20 0.50
BCHE P06276 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
SIGMAR1 Q99720 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29365732 0.97 HTR1A (0.73) HTR1ADRD1DRD2DRD3DRD5
Argemonine SCHEMBL3865650 0.87 HTR1A (0.58) HTR1ADRD1DRD2DRD3DRD5
Argemonine SCHEMBL30435899 0.87 HTR1A (0.58) HTR1ADRD1DRD2DRD3DRD5
Caryachine SCHEMBL6376741 0.85 HTR1A (1.00) HTR1ADRD1DRD2DRD3DRD5
Caryachine SCHEMBL29350783 0.85 HTR1A (1.00) HTR1ADRD1DRD2DRD3DRD5
SCHEMBL14703870 0.76 DRD1 (1.00) HTR1ADRD1DRD2DRD3DRD5
SCHEMBL14703833 0.76 DRD1 (1.00) HTR1ADRD1DRD2DRD3DRD5
SCHEMBL30298995 0.76 DRD1 (1.00) HTR1ADRD1DRD2DRD3DRD5
SCHEMBL14703834 0.76 DRD1 (1.00) HTR1ADRD1DRD2DRD3DRD5
Coreximine SCHEMBL30473249 0.76 DRD1 (1.00) HTR1ADRD1DRD2DRD3DRD5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260103736-A1 Methods Of Improving Production Of Morphinan Alkaloids And Derivatives ANTHEIA INC (US) 2026-04-16 US disclosed
US-12497638-B2 Methods of producing epimerases and benzylisoquinoline alkaloids THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2025-12-16 US disclosed
EP-3221461-B1 NOSCAPINOID-PRODUCING MICROBES AND METHODS OF MAKING AND USING THE SAME UNIV LELAND STANFORD JUNIOR (US) 2025-01-01 EP disclosed
US-20240218408-A1 Methods of Producing Epimerases and Benzylisoquinoline Alkaloids HERCULES CAPITAL, INC., AS AGENT 2024-07-04 US disclosed
US-11859225-B2 Methods of producing epimerases and benzylisoquinoline alkaloids THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2024-01-02 US disclosed
EP-4247937-A1 METHODS OF IMPROVING PRODUCTION OF MORPHINAN ALKALOIDS AND DERIVATIVES Antheia, Inc. (US) 2023-09-27 EP disclosed
US-20230203551-A1 Noscapinoid-producing Microbes and Methods of Making and Using the Same HERCULES CAPITAL, INC., AS AGENT 2023-06-29 US disclosed
EP-3294865-B1 METHODS OF PRODUCING EPIMERASES AND BENZYLISOQUINOLINE ALKALOIDS UNIV LELAND STANFORD JUNIOR (US) 2023-04-12 EP disclosed
US-11427827-B2 Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids ANTHEIA, INC. (US) 2022-08-30 US disclosed
WO-2022109194-A1 METHODS OF IMPROVING PRODUCTION OF MORPHINAN ALKALOIDS AND DERIVATIVES ANTHEIA, INC. (US) 2022-05-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260103736-A1 Methods Of Improving Production Of Morphinan Alkaloids And Derivatives OPRK1, OPRM1, OPRD1 HTR1A 94/4885DRD1 532/4885DRD2 618/4885
US-20230203551-A1 Noscapinoid-producing Microbes and Methods of Making and Using the Same NOS2, NISCH, NOS1 HTR1A 1035/4885DRD1 653/4885DRD2 641/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.