Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8872792 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2APOLBTSHR | |
| SCHEMBL29850888 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2APOLBTSHR | |
| SCHEMBL409745 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2APOLBTSHR | |
| SCHEMBL13258760 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2APOLBTSHR | |
| SCHEMBL8873096 | 0.77 | QTRT1 (0.49) | TYMS | |
| SCHEMBL15290198 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2APOLBTSHR | |
| SCHEMBL29850712 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2APOLBTSHR | |
| SCHEMBL9823085 | 0.72 | MMP13 (0.41) | SMN1; SMN2MEN1KMT2APOLBTSHR | |
| SCHEMBL9823173 | 0.72 | CTNNB1 (0.36) | SMN1; SMN2MEN1KMT2APOLBTSHR | |
| SCHEMBL9823392 | 0.72 | DHFR (0.40) | SMN1; SMN2MEN1KMT2APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5593999-A | Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT) | NAIR MADHAVAN G (US) | 1997-01-14 | — | — | US | disclosed |