Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.49 |
| ▸ | TYMS | P04818 | 5/20 | 0.44 |
| ▸ | DHFR | P00374 | 8/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5401637 | 0.85 | QTRT1 (0.47) | QTRT1TYMSDHFR | |
| SCHEMBL8874179 | 0.83 | DHFR (0.45) | TYMSDHFR | |
| SCHEMBL8872977 | 0.81 | QTRT1 (0.49) | QTRT1TYMSDHFR | |
| SCHEMBL30518413 | 0.78 | DHFR (0.70) | TYMSDHFR | |
| SCHEMBL8873027 | 0.77 | SMN1; SMN2 (0.40) | TYMS | |
| SCHEMBL28932180 | 0.75 | TYMS (0.56) | QTRT1TYMSDHFR | |
| SCHEMBL9954708 | 0.74 | TYMS (0.50) | QTRT1TYMSDHFR | |
| SCHEMBL6912192 | 0.71 | TYMS (0.50) | QTRT1TYMSDHFR | |
| SCHEMBL27812021 | 0.71 | TYMS (0.46) | QTRT1TYMSDHFR | |
| SCHEMBL28787846 | 0.70 | TYMS (0.54) | QTRT1TYMSDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5593999-A | Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT) | NAIR MADHAVAN G (US) | 1997-01-14 | — | — | US | disclosed |