Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.46 |
| ▸ | FPGS | Q05932 | 2/20 | 0.45 |
| ▸ | TYMS | P04818 | 2/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874179 | 0.85 | DHFR (0.45) | DHFRFPGSTYMSTNKS | |
| SCHEMBL8872977 | 0.84 | QTRT1 (0.49) | DHFRFPGSTYMS | |
| SCHEMBL4753487 | 0.79 | TNKS (0.51) | DHFRFPGSTYMSTNKS | |
| SCHEMBL30097387 | 0.78 | DHFR (0.59) | DHFRTYMS | |
| SCHEMBL2117452 | 0.72 | KDM4E (0.54) | TYMSTNKS | |
| SCHEMBL8872792 | 0.70 | SMN1; SMN2 (0.39) | TYMSTNKS | |
| SCHEMBL9954708 | 0.69 | TYMS (0.50) | DHFRFPGSTYMS | |
| SCHEMBL10597190 | 0.69 | LOXL2 (0.58) | — | |
| SCHEMBL28787846 | 0.69 | TYMS (0.54) | DHFRFPGSTYMS | |
| SCHEMBL409345 | 0.68 | DHFR (0.60) | DHFRFPGSTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5593999-A | Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT) | NAIR MADHAVAN G (US) | 1997-01-14 | — | — | US | disclosed |