SCHEMBL8874754

SCHEMBL8874754

CCC(C#N)CNC(=O)Cc1c(C)cc(C)cc1C

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.36
HTT P42858 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
ALDH1A1 P00352 3/20 0.34
CTSB P07858 4/20 0.33
P2RX7 Q99572 3/20 0.33
CTSL P07711 2/20 0.33
CTSS P25774 2/20 0.33
KDM4E B2RXH2 1/20 0.33
GAA P10253 1/20 0.33
PSMB5 P28074 1/20 0.33
TSHR P16473 2/20 0.33
LMNA P02545 2/20 0.32
USP2 O75604 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8874347 0.76 HTT (0.39) HPGDHTTNPSR1ALDH1A1P2RX7
SCHEMBL4241666 0.75 HPGD (0.42) HPGDP2RX7TSHRLMNAUSP2
SCHEMBL12845244 0.74 PSMB5 (0.40) CTSBCTSLCTSSPSMB5LMNA
SCHEMBL8988046 0.72 TDP1 (0.38) CTSBCTSLCTSSKDM4EPSMB5
SCHEMBL8874746 0.69 HPGD (0.38) HPGDHTTALDH1A1P2RX7KDM4E
SCHEMBL8744757 0.69 KMT2A (0.54) ALDH1A1
SCHEMBL8744747 0.69 KMT2A (0.54) ALDH1A1
SCHEMBL10398564 0.68 MTNR1A (0.36) ALDH1A1CTSSKDM4ETSHRUSP2
SCHEMBL9429635 0.68 HTT (0.33) HPGDHTTNPSR1ALDH1A1TSHR
Water SCHEMBL28215001 0.68 KDM4E (0.56) HPGDNPSR1ALDH1A1KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5672718-A PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-09-30 US disclosed
US-5508436-A INTERMEDIATES FOR PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1996-04-16 US disclosed