Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.59 |
| ▸ | DRD3 | P35462 | 4/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | HRH1 | P35367 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HRH2 | P25021 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8980652 | 0.99 | DRD2 (0.58) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL8877466 | 0.86 | DRD2 (0.59) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL8877327 | 0.86 | DRD2 (0.62) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL13254564 | 0.85 | DRD2 (0.66) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL7830825 | 0.83 | ADRA1A (0.62) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL1387894 | 0.83 | DRD2 (0.62) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL1193073 | 0.80 | DRD2 (0.75) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL9126731 | 0.80 | DRD2 (0.58) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL8875492 | 0.78 | DRD2 (0.57) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL8521957 | 0.78 | HTR1A (0.57) | DRD2DRD3HTR1AKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | disclosed |
| US-5474994-A | Treating hypertension, urethral and lower urinary tract contractions | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-12-12 | — | — | US | disclosed |