Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 11/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832834 | 0.88 | ADRA1A (0.62) | ADRA1AADRA1BADRA1DCYP3A4CYP2C9 | |
| SCHEMBL8875425 | 0.83 | DRD2 (0.59) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL7833743 | 0.83 | ADRA1A (0.57) | ADRA1AADRA1BADRA1DCYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL8980652 | 0.82 | DRD2 (0.58) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL9028727 | 0.80 | ADRA1A (0.60) | ADRA1AADRA1BADRA1DCYP3A4CYP2C9 | |
| SCHEMBL24712880 | 0.79 | DRD2 (0.59) | ADRA1AADRA1BADRA1DCYP3A4CYP2C9 | |
| SCHEMBL7961982 | 0.76 | L3MBTL1 (0.51) | ADRA1AADRA1BADRA1DCYP3A4CYP2C9 | |
| SCHEMBL24712881 | 0.76 | ADRA1A (0.49) | ADRA1AADRA1BADRA1DCYP3A4CYP2C9 | |
| SCHEMBL7835709 | 0.75 | ADRA1A (0.60) | ADRA1AADRA1BADRA1DCYP3A4CYP2C9 | |
| SCHEMBL6771682 | 0.75 | ADRA1A (0.60) | ADRA1AADRA1BADRA1DCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |