Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10842066 | 0.88 | LMNA (0.48) | LMNAMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL8876726 | 0.87 | LMNA (0.53) | LMNAMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL8876986 | 0.86 | MAPT (0.52) | LMNAMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL10840587 | 0.86 | LMNA (0.47) | LMNAMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL10841390 | 0.85 | LMNA (0.51) | LMNAMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL10842711 | 0.84 | ALDH1A1 (0.57) | LMNAMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL2480956 | 0.84 | LMNA (0.63) | LMNAMAPTSMN1; SMN2NPSR1GAA | |
| Hydrochloric Acid SCHEMBL10956791 | 0.83 | LMNA (0.61) | LMNAMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL8876180 | 0.82 | LMNA (0.60) | LMNAMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL10801206 | 0.81 | ALDH1A1 (0.48) | LMNAMAPTSMN1; SMN2NPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | disclosed |