Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6768095 | 0.82 | CYP1A2 (0.44) | SMN1; SMN2HTR7KDM4EHPGDSLC6A2 | |
| SCHEMBL7414992 | 0.81 | KDM4E (0.61) | SMN1; SMN2HTR7KDM4EHPGDHTR1A | |
| SCHEMBL22400198 | 0.81 | HSD17B10 (0.43) | SMN1; SMN2HTR7HPGDSLC6A2SLC6A4 | |
| SCHEMBL18883696 | 0.81 | CYP1A2 (0.56) | HPGDSLC6A3MAPTTDP1L3MBTL1 | |
| SCHEMBL4314586 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2HTR7KDM4EHPGDSLC6A2 | |
| SCHEMBL10458625 | 0.81 | KDM4E (0.41) | SMN1; SMN2HTR7KDM4EHPGDHTR1A | |
| SCHEMBL9323952 | 0.79 | PTGS2 (0.41) | SMN1; SMN2HTR7KDM4EHPGDHTR1A | |
| SCHEMBL6848695 | 0.79 | KDM4E (0.54) | SMN1; SMN2HTR7KDM4EHPGDMAPT | |
| SCHEMBL24495023 | 0.78 | NCF1 (0.44) | SMN1; SMN2HTR7KDM4EHPGDMAPT | |
| SCHEMBL11847000 | 0.78 | ALDH1A1 (0.52) | HTR7KDM4ESLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1040434-C | Heterobicyclic compounds | RECORDATI CHEM PHARM (CH) | 1998-10-28 | — | — | CN | disclosed |
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | disclosed |
| US-5474994-A | Treating hypertension, urethral and lower urinary tract contractions | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-12-12 | — | — | US | disclosed |
| WO-1993017007-A1 | HETEROBICYCLIC COMPOUNDS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 1993-09-02 | — | — | WO | disclosed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | disclosed |
| US-3932498-A | ANTIINFLAMMATORY, ANTIPYRETICS, ANALGESICS | MERCK & CO., INC. (US) | 1976-01-13 | — | — | US | disclosed |