Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877539 | 0.85 | ADRA1D (0.79) | SLC6A4ADRA1DDRD2KCNH2ADRA1B | |
| SCHEMBL8876794 | 0.83 | SLC6A4 (0.64) | SLC6A4ADRA1DDRD2ADRA1B | |
| SCHEMBL7256770 | 0.82 | ADRA1D (0.77) | SLC6A4ADRA1DDRD2KCNH2ADRA1B | |
| SCHEMBL9057605 | 0.81 | ADRA1D (0.56) | SLC6A4ADRA1DKCNH2CCR2 | |
| SCHEMBL8879141 | 0.80 | SLC6A4 (0.60) | SLC6A4ADRA1DDRD2ADRA1BCCR2 | |
| SCHEMBL8877925 | 0.80 | SLC6A4 (0.60) | SLC6A4ADRA1DDRD2 | |
| SCHEMBL5705230 | 0.80 | SLC6A4 (0.90) | SLC6A4ADRA1D | |
| SCHEMBL9057602 | 0.79 | KCNH2 (0.49) | SLC6A4ADRA1DDRD2KCNH2ADRA1B | |
| SCHEMBL7884112 | 0.79 | HTR1A (0.51) | SLC6A4ADRA1DDRD2KCNH2CCR2 | |
| SCHEMBL8878693 | 0.78 | SLC6A4 (0.78) | SLC6A4ADRA1DDRD2KCNH2ADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| CN-1133840-A | Indolepiperidine derivatives | MERCK PATENT GMBH (DE) | 1996-10-23 | — | — | CN | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |