Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876701 | 0.94 | CCR2 (0.56) | CCR2DRD2DRD4HTR2ADRD3 | |
| SCHEMBL8878677 | 0.88 | CCR2 (0.54) | CCR2DRD2HTR2ADRD3TP53 | |
| SCHEMBL8876762 | 0.88 | CCR2 (0.54) | CCR2DRD2DRD4DRD3 | |
| SCHEMBL8878073 | 0.88 | CCR2 (0.56) | CCR2DRD2HTR2A | |
| SCHEMBL8877476 | 0.88 | CCR2 (0.53) | CCR2DRD2DRD4DRD3 | |
| SCHEMBL9034812 | 0.86 | CCR2 (0.50) | CCR2DRD2OPRM1OPRK1OPRL1 | |
| SCHEMBL8878336 | 0.86 | CCR2 (0.48) | CCR2DRD2DRD4HTR2ADRD3 | |
| SCHEMBL8877860 | 0.86 | DRD2 (0.57) | CCR2DRD2DRD4HTR2ADRD3 | |
| SCHEMBL8876932 | 0.86 | ADRA1D (0.54) | CCR2DRD2DRD4HTR2A | |
| SCHEMBL8878088 | 0.86 | CCR2 (0.56) | CCR2DRD2OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |