SCHEMBL887879

SCHEMBL887879

Nc1nc(-c2nccs2)c2nc[nH]c2n1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 12/20 0.50
ADORA1 P30542 11/20 0.50
HSP90AA1 P07900 1/20 0.41
ADORA3 P0DMS8 4/20 0.40
ADORA2B P29275 4/20 0.40
KDM4A O75164 1/20 0.35
KDM4B O94953 1/20 0.35
KDM5C P41229 1/20 0.35
KDM5B Q9UGL1 1/20 0.35
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
NOS1 P29475 1/20 0.33
HSD17B10 Q99714 1/20 0.33
GSK3A P49840 2/20 0.33
GSK3B P49841 2/20 0.33
TGFBR1 P36897 1/20 0.33
LOXL2 Q9Y4K0 1/20 0.32
PDPK1 O15530 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27816449 0.88 ADORA2A (0.45) ADORA2AADORA1HSP90AA1ADORA3ADORA2B
SCHEMBL887880 0.76 PDPK1 (0.51) ADORA2AADORA1HSP90AA1PDPK1
SCHEMBL14002419 0.75 CYP2A6 (0.38) ADORA2AADORA1KDM4AKDM4BKDM5C
SCHEMBL540121 0.75 ADORA2A (0.49) ADORA2AADORA1ADORA3ADORA2BKDM5B
SCHEMBL14002404 0.72 ADORA2A (0.41) ADORA2AADORA1ADORA3ADORA2BKDM4A
SCHEMBL30162844 0.70 CHUK (0.48) ADORA2AADORA1ADORA3ADORA2BALDH1A1
SCHEMBL2933188 0.70 CHUK (0.48) ADORA2AADORA1ADORA3ADORA2BALDH1A1
SCHEMBL16265999 0.70 ADORA2A (0.41) ADORA2AADORA1ADORA3ADORA2BALDH1A1
2,6-Diaminopurine SCHEMBL24052 0.69 GDA (0.48) ADORA2AADORA3ALDH1A1PDPK1
2,6-Diaminopurine SCHEMBL29444619 0.69 GDA (0.48) ADORA2AADORA3ALDH1A1PDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3401407-A1 NUCLEIC ACID PROBE, METHOD FOR DESIGNING NUCLEIC ACID PROBE, AND METHOD FOR DETECTING TARGET SEQUENCE Kabushiki Kaisha Dnaform (JP) 2018-11-14 EP claimed
US-10066264-B2 Method for analyzing target nucleic acid, kit, and analyzer KABUSHIKI KAISHA DNAFORM (JP) 2018-09-04 US claimed
EP-2873731-B1 NUCLEIC ACID PROBE, METHOD FOR DESIGNING NUCLEIC ACID PROBE, AND METHOD FOR DETECTING TARGET SEQUENCE DNAFORM KK (JP) 2018-08-29 EP claimed
EP-2891714-B1 METHOD FOR ANALYZING TARGET NUCLEIC ACID, KIT, AND ANALYZER DNAFORM KK (JP) 2018-07-11 EP claimed
US-9862989-B2 Nucleic acid probe, method for designing nucleic acid probe, and method for detecting target sequence KABUSHIKI KAISHA DNAFORM (JP) 2018-01-09 US claimed
US-20150203902-A1 NUCLEIC ACID PROBE, METHOD FOR DESIGNING NUCLEIC ACID PROBE, AND METHOD FOR DETECTING TARGET SEQUENCE KABUSHIKI KAISHA DNAFORM (JP) 2015-07-23 US claimed
EP-2891714-A1 METHOD FOR ANALYZING TARGET NUCLEIC ACID, KIT, AND ANALYZER Kabushiki Kaisha Dnaform (JP) 2015-07-08 EP claimed
US-20150152496-A1 METHOD FOR ANALYZING TARGET NUCLEIC ACID, KIT, AND ANALYZER KABUSHIKI KAISHA DNAFORM (JP) 2015-06-04 US claimed
EP-2873731-A1 NUCLEIC ACID PROBE, METHOD FOR DESIGNING NUCLEIC ACID PROBE, AND METHOD FOR DETECTING TARGET SEQUENCE Kabushiki Kaisha Dnaform (JP) 2015-05-20 EP claimed
US-8067162-B2 Replication; hybridization; kits RIKEN (JP) 2011-11-29 US claimed
US-10760116-B2 Analysis kit, analyzer, and methods for analyzing template nucleic acid or target substance KABUSHIKI KAISHA DNAFORM (JP) 2020-09-01 US disclosed
EP-3339447-B1 METHOD FOR ANALYZING TEMPLATE NUCLEIC ACID, METHOD FOR ANALYZING TARGET SUBSTANCE, ANALYSIS KIT FOR TEMPLATE NUCLEIC ACID OR TARGET SUBSTANCE, AND ANALYZER FOR TEMPLATE NUCLEIC ACID OR TARGET SUBSTANCE DNAFORM KK (JP) 2020-07-29 EP disclosed
EP-3401407-B1 NUCLEIC ACID PROBE, METHOD FOR DESIGNING NUCLEIC ACID PROBE, AND METHOD FOR DETECTING TARGET SEQUENCE DNAFORM KK (JP) 2020-04-22 EP disclosed
US-10428371-B2 Fluorescent labeled single-stranded nucleic acid and use thereof KABUSHIKI KAISHA DNAFORM (JP) 2019-10-01 US disclosed
US-20190032108-A1 METHOD FOR ANALYZING TEMPLATE NUCLEIC ACID, METHOD FOR ANALYZING TARGET SUBSTANCE, ANALYSIS KIT FOR TEMPLATE NUCLEIC ACID OR TARGET SUBSTANCE, AND ANALYZER FOR TEMPLATE NUCLEIC ACID OR TARGET SUBSTANCE RIKEN (JP) 2019-01-31 US disclosed
US-20090275017-A1 Novel Nucleoside or Nucleotide Derivative and Use Thereof RIKEN (JP) 2009-11-05 US disclosed
US-20080227104-A1 Replication; hybridization; kits RIKEN (JP) 2008-09-18 US disclosed
EP-1970453-A2 Primer, primer set, and nucleic acid amplification method and mutation detection method using the same Riken (JP) 2008-09-17 EP disclosed
EP-1970445-A1 METHOD FOR NUCLEIC ACID REPLICATION AND NOVEL ARTIFICIAL BASE PAIRS Riken (JP) 2008-09-17 EP disclosed
EP-1816130-A1 NOVEL NUCLEOSIDE OR NUCLEOTIDE DERIVATIVE AND USE THEREOF Riken (JP) 2007-08-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090275017-A1 Novel Nucleoside or Nucleotide Derivative and Use Thereof DUT, NT5C3B, NT5C ADORA2A 889/4885ADORA1 1454/4885HSP90AA1 4193/4885
US-20080227104-A1 Replication; hybridization; kits PCNA, POLL, RNGTT ADORA2A 4447/4885ADORA1 2969/4885HSP90AA1 2906/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.