Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.74 |
| ▸ | BRD4 | O60885 | 2/20 | 0.57 |
| ▸ | PTAFR | P25105 | 15/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8928436 | 0.89 | OPRK1 (0.77) | OPRK1PDE4DBRD4PTAFRLMNA | |
| SCHEMBL10465293 | 0.88 | PTAFR (0.62) | OPRK1PDE4DBRD4PTAFRLMNA | |
| SCHEMBL9522870 | 0.88 | PTAFR (0.62) | OPRK1PDE4DBRD4PTAFRLMNA | |
| SCHEMBL8928788 | 0.86 | OPRK1 (0.56) | OPRK1PDE4DBRD4PTAFRLMNA | |
| Etizolam SCHEMBL42920 | 0.85 | OPRK1 (1.00) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Etizolam SCHEMBL30665015 | 0.85 | OPRK1 (1.00) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL9669241 | 0.82 | PTAFR (0.56) | OPRK1PDE4DBRD4PTAFRLMNA | |
| SCHEMBL9864381 | 0.81 | OPRK1 (0.57) | OPRK1PDE4DPTAFRLMNACYP3A4 | |
| Etizolam SCHEMBL10869413 | 0.81 | OPRK1 (0.90) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL8928407 | 0.80 | OPRK1 (0.79) | OPRK1PDE4DPTAFRGABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5593988-A | DIAZIPINE DERIVATIVES OF THIOPHENE FOR BONE DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-01-14 | — | — | US | disclosed |
| EP-0661284-A1 | THIENODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |
| EP-0638560-A1 | REMEDY FOR OSTEOPOROSIS AND DIAZEPINE COMPOUND | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |