Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8880656 | 0.87 | METAP1 (0.38) | MAPTMAPK1ATMGABRA1GABRG2 | |
| SCHEMBL8880066 | 0.85 | HRH1 (0.43) | MAPTMAPK1GABRA1GABRG2GABRB3 | |
| SCHEMBL8881385 | 0.85 | GABRG2 (0.41) | MAPTMAPK1ATMGABRA1GABRG2 | |
| SCHEMBL8880563 | 0.85 | GABRG2 (0.38) | MAPTGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8880818 | 0.85 | ACHE (0.41) | MAPTMAPK1ATMGABRA1GABRG2 | |
| SCHEMBL8882302 | 0.85 | GABRG2 (0.40) | MAPTMAPK1GABRA1GABRG2GABRB3 | |
| SCHEMBL8097517 | 0.85 | KMT2A (0.43) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8881566 | 0.85 | ACHE (0.40) | MAPTMAPK1ATMGABRA1GABRG2 | |
| SCHEMBL8883880 | 0.84 | RAB9A (0.39) | MAPTMAPK1ATMGABRA1GABRG2 | |
| SCHEMBL8881176 | 0.84 | CYP19A1 (0.43) | MAPTMAPK1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5677306-A | ANTAGONIZING ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTOR, USEFUL FOR TREATING ALL ISCHEMIAS | RHONE-POULENC RORER S.A. (FR) | 1997-10-14 | — | — | US | disclosed |