Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169081 | 0.85 | HPGDS (0.65) | HPGDSLMNASMN1; SMN2HTTNPC1 | |
| SCHEMBL29419354 | 0.85 | HPGDS (0.65) | HPGDSLMNASMN1; SMN2HTTNPC1 | |
| SCHEMBL16787533 | 0.81 | HPGDS (0.53) | HPGDSLMNASMN1; SMN2HTTNPC1 | |
| SCHEMBL18326334 | 0.80 | ALOX5 (0.56) | LMNASMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL19419913 | 0.79 | TP53 (0.56) | LMNASMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL3282912 | 0.79 | NPC1 (0.63) | LMNASMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL29861033 | 0.79 | NPC1 (0.63) | LMNASMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL1415715 | 0.78 | HPGDS (0.50) | HPGDSSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL2097494 | 0.76 | HPGDS (0.54) | HPGDSLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL29586157 | 0.76 | HPGDS (0.54) | HPGDSLMNASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684015-A | ANGIOTENSIN ANTAGONIST AS HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5438063-A | Hypotensive agents, cardiac insufficiency, increased intraocular pressure, and CNS disorders | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-08-01 | — | — | US | disclosed |